Lillian Travers, a New York heiress, pops down to Florida to surprise her fiancé, Fred Cassadene, the house doctor at a prominent Saint Augustine hotel. The surprise, however, is Lillian's when she finds Fred in a series of compromising situations with a certain wealthy widow staying there. When she can take no more, Lillian discovers a box forgotten at an old curiosity shop in which lies a hundred-year-old secret: a vial of four rare and exotic African seeds that promises to transform whoever swallows one from a woman to a man or vice versa.

• Vitagraph Company of America
• Sidney Drew
• Mrs. Sidney Drew
• Edith Storey
• Charles Kent
• Ada Gifford
• Ethel Lloyd
• Lillian Burns
• Grace Stevens